Clexane® is an anticoagulant of the low-molecular-weight heparin (LMWH) class, derived from natural porcine heparin, to treat thrombosis1.
Clexane is available in two different devices as seen below. There are several different doses of CLEXANE, so the syringes may look slightly different from the ones shown here.
Automatic release of the safety mechanism when the plunger is fully depressed.
Needle completely covered by the protection cap immediately after the injection.
Release of the safety mechanism when the plunger is depressed after the injection.
An audiable “click” confirms the activation of the safety mechanism.
You will find the instructions of how to use Clexane and more information in the material below.
The prophylaxis of venous thromboembolism (VTE)2:
The treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), excluding PE likely to require thrombolytic therapy or surgery2:
Clexane® exerts its anticoagulant effect by preventing the formation of blood clots through binding to antithrombin, a naturally occurring coagulation inhibitor and potentiating its action3.
Antithrombin is a natural inhibitor of the coagulation factors FXIa, FIXa, FXa and FIIa (thrombin)3.
Clexane® forms a complex with antithrombin. This complex undergoes a conformational change; in its altered conformation, the complex inhibits FXa, which is the primary mechanism of action. It also inhibits FIIa, although to a lesser extent - in vitro, Clexane has a high anti-Xa activity and low anti-IIa or anti thrombin activity, with a ratio of 3.62.
MAT-GB-2100351 (v3.0) August 2021