The key pharmacokinetic properties of Clexane®  include:
Clexane® is predominantly metabolised in the liver by desulfation or depolymerisation to lower molecular weight species and is eliminated renally . A linear relationship between anti-Xa plasma clearance and creatinine clearance at steady-state has been observed, which indicates decreased clearance of enoxaparin sodium in patients with reduced renal function. In patients with severe renal impairment (creatinine clearance < 30 ml/min), the AUC at steady state is significantly increased by an average of 65% after repeated, once daily subcutaneous doses of 4,000 IU (40 mg).
Since renal function is known to decline with age, elderly patients may show reduced elimination of enoxaparin sodium.
Clexane®, as detected by anti-Xa activity, does not cross the placental barrier during the second and third trimester of pregnancy .
No pharmacokinetic interactions were observed between Clexane® and thrombolytics when administered concomitantly . Enoxaparin sodium should be used during pregnancy only if the physician has established a clear need.
There are special warnings and precautions for use in patients with renal impairment, the elderly, in obese patients and pregnant women. Please refer to section 4.4 of the SmPC for use of Clexane® in these patients.