Surgery and Hospitalisation

Surgery is a well-known risk factor for VTE

  • Cancer surgery increases the risk of postoperative DVT 2-fold and that of fatal PE by >3-fold compared with non-cancer patients
Chemotherapy and angiogenesis inhibitors

have a strong association with VTE

  • Cancer patients have a 6- to 7-fold increased risk of developing chemotherapy-associated thrombosis
  • Combination chemotherapy with cisplatin increases thrombotic complications in patients with GI cancers
  • Other treatments, such as L-asparganase, thalidomide, lenalidomide, hormonal therapy and erythropoiesis-stimulating agents, have also been reported to increase the risk of VTE

It can affect the result of VTE anticoagulant therapy in cancer patients. Ionizing radiation influences protein C pathway and its thrombomodulin interaction2

  • Use of central venous catheters can result in the formation of catheter-related thrombosis, a serious complication that can interrupt chemotherapy, blood products, or intravenous medications1
  • Indwelling CVC can increase risk for developing VTE. Estimated rate of symptomatic catheter-related DVT is between 0.3 and 28%1


  1. Abdol Razak NB et al. Cancers. 2018, 10, 380
  2. Guy J et al. Crit Rev Oncol Hematol. 2017 May;113:83-8


MAT-GB-2000453 (v5.0) Date of preparation: March 2022